Address.

Education.

Academic and Research Experience.

Technical Experience.

Publications:

• L. Cruz, B. Urbanc, D. L. Roe, A. Inglis, H. E. Stanley, and D. L. Rosene, ``Computer simulations of the effects of aging in the brain,'' in preparation (2008).
  
  
• B. Urbanc, L. Cruz, and G. Bitan, ``In silico study of amyloid beta-protein oligomer formation in the presence of peptide inhibitors,'' in preparation (2008).
  
  
• L. Cruz, B. Urbanc, N. D. Lazo, D. B. Teplow, and H. E. Stanley, ``Comparative analysis of the Artic and Iowa mutations on the nucleation of the Abeta-protein: an all-atom molecular dynamics study,'' in preparation (2008).
  
  
• S. Yun, S. Peng, B. Urbanc, S. V. Buldyrev, L. Cruz, D. B. Teplow, and H. E. Stanley, ``Discrete Molecular Dynamics Study of Abeta16-22 Folding and Aggregation,'' in preparation (2008).
  
  
• L. Cruz, D. L. Roe, B. Urbanc, A. Inglis, H. E. Stanley, and D. L. Rosene, ``Age-related reduction in microcolumnar structure correlates with cognitive decline in the ventral but not dorsal region part of area 46 of the rhesus monkey,'' Neuroscience, 158, 1509-1520 (2009). [PDF]
  
  
• S. H. Freeman, R. Kandel, L. Cruz, A. Rozkalne, K. Newell, M. P. Frosch, E. T. Hedley-Whyte, J. J. Locascio, L. Lipsitz, B. T. Hyman, ``Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects Without Alzheimer Disease,'' Journal of Neuropathology and Experimental Neurology, 67, 1205-1212 (2008).
  
  
• E. A. Fradinger, B. H. Monien, B. Urbanc, A. Lomakin, M. Tan, H. Li, S. M. Spring, M. M. Condron, L. Cruz, C.-W. Xie, G. B. Benedek, and G. Bitan, ``C-terminal peptides coassemble into A$\beta$42 oligomers and protect neurons against Abeta42-induced neurotoxicity,'' Proc. Natl. Acad. Sci., 105, 14175-14180 (2008).
  
  
• A. Inglis, L. Cruz, D. L. Roe, H. E. Stanley, D. L. Rosene, and B. Urbanc, ``Automated indentification of neurons and their locations,'' Journal of Microscopy, 230(3), 339-347 (2007).
  
  
• L. Cruz, B. Urbanc, A. Inglis, D. L. Rosene, and H. E. Stanley, ``Generating a model of the Three-dimensional Spatial Distribution of Neurons using Density Maps,'' NeuroImage 40 (3), 1105-1115 (2008). [PDF]
  
  
• S. Yun, B. Urbanc, L. Cruz, G. Bitan, D. B. Teplow, and H. E. Stanley, ``Role of electrostatic interactions in amyloid beta-protein oligomer formation: A discrete molecular dynamics study,'' Biophys Journal 92, 4064-4077 (2007). [PDF]
  
  
• B. Urbanc, L. Cruz, D. B. Teplow, and H. E. Stanley, ``Computer simulations of Alzheimer's amyloid beta-protein folding and assembly,'' invited review paper, Current Alzheimer Research, 3, 493-504 (2006). [PDF]
  
  
• D. B. Teplow, N. D. Lazo, G. Bitan, S. Bernstein, T. Wyttenbach, M. T. Bowers, A. Baumketner, J.-E. Shea, B. Urbanc, L. Cruz, J. Borreguero, H. E. Stanley, ``Elucidating Amyloid beta-Protein Folding and Assembly: A Multidisciplinary Approach,'' Accounts of Chemical Research, 39, 635-645 (2006). [PDF]
  
  
• B. Urbanc, J. M. Borreguero, L. Cruz, and H. E. Stanley, ``Ab initio Discrete Molecular Dynamics Approach to Protein Folding and Aggregation,'' Methods in Enzymology, 412, p. 314-338 (2006). [PDF]
  
  
• L. Cruz, B. Urbanc, J. M. Borreguero, N. D. Lazo, D. B. Teplow, and H. E. Stanley, ``Solvent and Mutation Effects on the Nucleation of Amyloid $\beta$-protein Folding,'' Proc. Natl. Acad. Sci., 102, p. 18258-18263 (2005). [PDF]
  
  
• L. Cruz, S. V. Buldyrev, S. Peng, D. L. Roe, B. Urbanc, H. E. Stanley, and D. L. Rosene, ``A Statistically Based Density Map Method for Identification and Quantification of Regional Differences in Microcolumnarity in the Monkey Brain,'' J. Neuroscience Methods, 141/2, p. 321-332 (2005). [PDF]
  
  
• B. Urbanc, L. Cruz, S. Yun, S. V. Buldyrev, G. Bitan, D. B. Teplow, and H. E. Stanley, ``In silico study of amyloid beta-protein folding and oligomerization,'' Proc. Natl. Acad. Sci., 101, p. 17345-17350 (2004). [PDF]
  
  
• L. Cruz, D. L. Roe, B. Urbanc, H. Cabral, H. E. Stanley, and D. L. Rosene, ``Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline,'' Proc. Natl. Acad. Sci., 101, p. 15846-15851 (2004). [PDF]
  
  
• B. Urbanc, L. Cruz, F. Ding, D. Sammond, S. Khare,S. V. Buldyrev, H. E. Stanley, and N. V. Dokholyan, ``Molecular Dynamics Simulation of Amyloid beta Dimer Formation,'' Biophys. J., 87, p. 2310-2321 (2004). [PDF]
  
  
• S. Peng, F. Ding, B. Urbanc, S. V. Buldyrev, L. Cruz, H. E. Stanley, and N. V. Dokholyan, ``Discrete molecular dynamics simulations of peptide aggregation,'' Phys. Rev. E, 69, 041908, (2004). [PDF]
  
  
• S. Peng, B. Urbanc, L. Cruz, B. T. Hyman, and H. E. Stanley, ``Neuron Recognition by Parallel Potts Segmentation,'' Proc. Natl. Acad. Sci., 100, p. 3847-3852 (2003). [PDF]
  
  
• B. Urbanc, L. Cruz, R. Le, J. Sanders, K. Hsiao-Ashe, K. Duff, H. E. Stanley, M. C. Irrizarry and B. T. Hyman, "Neurotoxic Effects of Thioflavin S Positive Amyloid Deposits in Transgenic Mice and Alzheimer's Disease," Proc. Natl. Acad. Sci., 99, p. 13990-13995 (2002). [PDF]
  
  
• R. Le, L. Cruz, B. Urbanc, R. B. Knowles, K. Hsiao-Ashe, K. Duff, M. C. Irizarry, H. E. Stanley and B. T. Hyman, "Plaque-Induced Abnormalities in Neurite Geometry in Transgenic Models of Alzheimer Disease: Implications for Neural System Disruption," J. Neuropath. Exp. Neuro., 60, p. 753-758 (2001).
  
  
• Contributor to the "Dictionary of Pure and Applied Physics," a volume in the Comprehensive Dictionary of Physics, ed. B. Basu, CRC Press, Florida, USA (2001).
  
  
• S. V. Buldyrev, L. Cruz, T. Gomez-Isla, E. Gomez-Tortoza, S. Havlin, R. Le, H. E. Stanley, B. Urbanc and B. T. Hyman, "Disruption of Neuronal Microcolumnar Architecture in Alzheimer and Lewy Body Dementias," Proc. Natl. Acad. Sci. 97, p. 5039-5043 (2000). [PDF]
  
  
• B. Urbanc, L. Cruz, S. V. Buldyrev, S. Havlin, B. T. Hyman, and H. E. Stanley, "Dynamic Feedback in an Aggregation- Disaggregation Model," Phys. Rev. E 60, 2120-2126 (1999). [PDF]
  
  
• B. Urbanc, L. Cruz, S. V. Buldyrev, S. Havlin, M. C. Irizarry, H. E. Stanley, and B. T. Hyman, "Dynamics of Plaque Formation in Alzheimer Disease," Biophys. J. 76, 1330-1334 (1999). [PDF]
  
  
• R. B. Knowles, C. Wyart, S. V. Buldyrev, L. Cruz, B. Urbanc, M. E. Hasselmo, H. E. Stanley, and B. T. Hyman, "Plaque-Induced Neural Network Disruption in Alzheimer's Disease," Proc. Natl. Acad. Sci. 96, 5274-5279 (1999). [PDF]
  
  
• B. T. Hyman, R. B. Knowles, C. Wyart, S.V. Buldyrev, L. Cruz, B. Urbanc, M. E. Hasselmo, and H. E. Stanley, "Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer's disease," J. Neuropath. Exp. Neurol. 58, 557-557 (1999).
  
  
• H. E. Stanley, S. V. Buldyrev, L. Cruz, T. Gomez-Isla, S. Havlin, B. T. Hyman, R. Knowles, B. Urbanc and C. Wyart, "Statistical Physics and Alzheimer's Disease," [Proc. Bar-Ilan Conf], Physica A 249, 460-471 (1998). [PDF]
  
  
• L. Cruz, B. Urbanc, S. V. Buldyrev, R. Christie, T. Gomez-Isla, S. Havlin, M. McNamara, H. E. Stanley, B. T. Hyman, "Aggregation and disaggregation of Senile Plaques in Alzheimer Disease," Proc. Natl. Acad. Sci. 94, 7612-7616 (1997). [PDF]
  
  
• R. B. Knowles, L. Cruz, B. Kutnjak-Urbanc, R. H. Christie, H. E. Stanley HE, and B. T. Hyman, "The effect of senile plaques and neuropil threads on neurite morphology in Alzheimer's disease," Neurology 48, 3045-3045 Suppl. 2, (1997).
  
  
• B. Urbanc and L. Cruz, "Order Parameter and Segregated Phases in a Sandpile Model with Two Particle Sizes," Phys. Rev. E 56, 1571-1579 (1997). [PDF]
  
  
• H. E. Stanley, L. Cruz, S. T. Harrington, P. H. Poole, S. Sastry, F. Sciortino, F. W. Starr, and R. Zhang, "Cooperative Molecular Motions in Water: The Liquid-Liquid Critical Point Hypothesis," [Proc. International Conf. on "Complex Fluids"] Physica A 236, 19-37 (1997). [PDF]
  
  
• L. Cruz, P .Phillips, A. Castro-Neto, "Kondo Resonance and log-T Conductivity in Highly Conducting trans-Polyacetylene," Europhysics Letters 29, 389-394 (1995).
  
  
• L. Cruz, P. Phillips, "Phase Diagram for Strongly-Correlated Doped trans Polyacetylene," Physical Review B 49, 5149-5156 (1994). [PDF]
  
  
• P. Phillips, L. Cruz, "Metallic Polyacetylene is a Soliton Lattice," Synth. Met. 65, 225-232 (1994).
  
  
• L. Fonseca, M. Gomez, L. Cruz, "Calculation of the Aggregation and Electrodynamic Effects in Granular Systems," Physica A 207, 123-130 (1994).
  
  
• Q. Li, L. Cruz, P. Phillips, "Granular-rod Model for Electronic Conduction in Polyaniline," Physical Review B 47 , 1840-1845 (1993). [PDF]
  
  
• Q. Li, L. Cruz, P. Phillips, "Dimers and Rods in the Conducting States of Polyaniline," Synth. Met. 55-57, 4697-4703 (1993).
  
  
• W. Vargas, L. Cruz, L. Fonseca, M. Gomez, "T-Matrix Approach for Calculating Local Fields around Clusters of Rotated Spheroids," App. Opt. 32, 2164-2170 (1993). [PDF]
  
  
• L. Fonseca, L. Cruz, M. Gomez, J. A. Gonzalo, "Determination of sizes of Potassium Colloids in KCl:O using Light Scattering Techniques," App. Phys. Comm. 12, 153 (1993).
  
  
• L. Fonseca, L. Cruz, W. Vargas, M. Gomez, "Theoretical Calculation of the Optical Absorption of Fractal Colloidal Aggregates Using a Multiple Scattering Formalism," Condensed Matter Theories 8, 561, ed. L.Blum, F.B.Malik, Plenum Press, N.Y. (1993).
  
  
• M. Gomez, L. Fonseca, L. Cruz, W. Vargas, "Calculation of Local Fields for Clusters of Ellipsoids within the T-Matrix Approach," Mat. Res. Soc. Symp. Proceedings 195, 109 (1990).
  
  
• L. Cruz, L. Fonseca, M. Gomez, "T-Matrix Approach for the Calculation of Local Fields in the Neighborhood of Small Clusters in the Electrodynamic Regime," Physical Review B 40, 7491-7500 (1989). [PDF]
  
  
• M. Gomez, L. Fonseca, L. Cruz, "Local Electric Field Enhancements in Composite Materials due to Metallic Clusters," Proc. of the Intl. Workshop on: Electrodynamics of Interfaces and Composite Systems 4, 447, ed. R.G.Barrera, W.L.Mochan, World Scientific, N.J. (1987).
  
  
• M. Gomez, L. Fonseca, G. Rodriguez, A. Velazquez, L. Cruz, "Multiple Scattering theories including Correlation effects to obtain the Effective Dielectric Constant of Non-Homogeneous Thin Films," Physical Review B 32, 3429-3441 (1985). [PDF]